Ozzie Cox (Malkovich) is a CIA vet who is fired because he is an alcoholic. He takes his revenge by writing some inflammatory memoirs. Cox's soon-to-be ex-wife Katie (Swindon) steals the disc containing his memoirs and accidentally leaves it at the gym where it is found by a trainer, Chad Feldheimer (Pitt) and the gym's owner, Linda Litzke (McDormand). They believe they can use the info to blackmail Cox.
Harry Pfarrer (Clooney) is an oversexed, fanatically fit, lactose-intolerant federal marshal who is sleeping with Cox's wife. He meets Linda via an online dating service and gets entangled in the blackmail scheme, when he stumbles across Chad breaking into his and Katie's house.
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